MRTX-1257
MRTX-1257 is a potent, covalent, and selective KRAS G12C inhibitor with an IC50 of 900 pM in cellular assays. It demonstrates good oral bioavailability in mice and achieves significant in vivo target engagement, supporting its use in both in vitro mechanistic studies and in vivo efficacy models for KRAS-driven cancers.
Product Specifications
CAS Number
2206736-04-9
Product Name Alternative
Covalent, cancer, ERK, G12C, H358 cells, inhibit, irreversible, mutant, MRTX1257, MRTX-1257, MRTX 1257, KRAS, KRAS (G12C), KRAS G12C, Inhibitor, selective, phosphorylation, Ras
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
96.59% (May vary between batches)
Solubility
DMSO:35 mg/mL (61.87 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.54 mM)
Smiles
CN1CCC[C@H]1COc1nc2CN (CCc2c (n1) N1CCN ([C@@H] (CC#N) C1) C (=O) C=C) c1cccc2cccc (C) c12
Molecular Formula
C33H39N7O2
Molecular Weight
565.71
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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