MRX-2843
MRX-2843 (UNC2371) is a potent, orally bioavailable small molecule inhibitor targeting MERTK and FLT3 with IC50 values of 1.3 nM and 0.64 nM, respectively. It is a valuable research tool for studying oncology, particularly in acute myeloid leukemia (AML), and has demonstrated activity in both cellular assays and in vivo tumor models.
Product Specifications
CAS Number
1429882-07-4
Product Name Alternative
MRX-2843, MRX 2843, MRX2843, inhibit, MERTK, Inhibitor, FLT3, Fms like tyrosine kinase 3, CD135, Cluster of differentiation antigen 135, UNC2371, UNC-2371, UNC 2371
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.59% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.09 mM) ; DMSO:26.25 mg/mL (53.72 mM)
Smiles
CN1CCN (Cc2ccc (cc2) -c2cn ([C@H]3CC[C@H] (O) CC3) c3nc (NCCC4CC4) ncc23) CC1
Molecular Formula
C29H40N6O
Molecular Weight
488.67
Storage Conditions
-20°C
Notes
For research use only.
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