MT 63-78
MT 63-78 is a direct AMPK activator (EC50: 25 μM) with demonstrated antitumor activity. It inhibits prostate cancer cell growth in vitro by suppressing lipogenesis and mTORC1 signaling, leading to cell cycle arrest and apoptosis. Its effects have also been explored in relevant in vivo xenograft models.
Product Specifications
CAS Number
1179347-65-9
Product Name Alternative
Direct, dephosphorylation, AMP-activated protein kinase, BH3, Apoptosis, antitumor, AMPK, arrest, MT 63 78, MT 6378, MT 63-78, mTOR, mTORC1, inhibit, p53, lipogenesis, mitotic, Mcl-1, Mammalian target of Rapamycin, Inhibitor, Thr172, Raptor
Field of Research
Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
97.11% (May vary between batches)
Solubility
DMSO:3.27 mg/mL (10.02 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.06 mM)
Smiles
Oc1cccc (O) c1-c1ccc (cc1) -c1ccc2[nH]cc (C#N) c2c1
Molecular Formula
C21H14N2O2
Molecular Weight
326.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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