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Mutant IDH1 inhibitor

This small molecule inhibitor potently targets the mutant IDH1 R132H enzyme with an IC50 under 72 nM. It is a valuable research tool for investigating oncogenic mechanisms in models of glioma and AML, supporting both in vitro and in vivo studies.

Product Specifications

CAS Number

1429180-08-4

Product Name Alternative

IsocitrateDehydrogenase, IsocitrateDehydrogenase (IDH), Isocitrate Dehydrogenase (IDH), Mutant IDH1 inhibitor, Mutant IDH-1 inhibitor, mutant IDH1 R132H, Isocitrate Dehydrogenase, inhibit, IDH, Inhibitor

Field of Research

Metabolism Research, Metabolism Research; Pharmacology & Drug Discovery

Purity

97.72% (May vary between batches)

Solubility

DMSO:30 mg/mL (64.3 mM)

Smiles

CC (C) [C@H]1COC (=O) N1c1ccnc (N[C@@H] (C) c2ccc (CN3CCN (CC3) C (C) =O) cc2) n1

Molecular Formula

C25H34N6O3

Molecular Weight

466.58

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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