Nimbolide
Nimbolide is a neem-derived triterpenoid that acts as a multi-pathway inhibitor, suppressing CDK4/6 kinase activity and disrupting NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling. Its induction of apoptosis via NF-κB inactivation supports its research use in oncology, with demonstrated effects in both cellular and animal models of cancer.
Product Specifications
CAS Number
25990-37-8
Product Name Alternative
CDK, CDK4, CDK6, Cyclin dependent kinase, Apoptosis, Inhibitor, inhibit, NFkB, NF-kB, NF-κB, NFκB, Nimbolide, Nuclear factor-kappaB, Nuclear factor-κB
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
95.84% (May vary between batches)
Solubility
DMSO:60 mg/mL (128.61 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.14 mM)
Smiles
C[C@]12[C@]3 ([C@] ([C@@]4 ([C@] (C) ([C@@H]1CC (OC) =O) C=5[C@] (O4) (C[C@H] (C5C) C=6C=COC6) [H]) [H]) (OC (=O) [C@]3 (C) C=CC2=O) [H]) [H]
Molecular Formula
C27H30O7
Molecular Weight
466.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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