OSMI-1
OSMI-1 is a cell-permeable, orally bioavailable small molecule inhibitor of O-GlcNAc transferase (OGT) with an IC50 of 2.7 μM. It selectively reduces protein O-GlcNAcylation in cellular and in vivo models without broadly affecting other glycosylation pathways, making it a valuable research tool for studying nutrient sensing, cellular stress, and transcriptional regulation.
Product Specifications
CAS Number
1681056-61-0
Product Name Alternative
Diglyceride acyltransferase, Diacylglycerol acyltransferase, cell-permeable, acyl-CoA:cholesterol acyltransferase, Acyltransferase, Inhibitor, inhibit, OSMI 1, OSMI1, OSMI-1, O-GlcNAc, O-GlcNAc transferase, O-GlcNAc transferase (OGT), O-GlcNAcylation, OGT, mono- acylglycerol acyltransferase, mammalian, toxicity, zebrafish, transferase
Field of Research
Metabolism Research
Purity
96.79% (May vary between batches)
Solubility
DMSO:104 mg/mL (184.51 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.83 mg/mL (3.25 mM)
Smiles
O=C (N (CC1=CC=CS1) CC2=CC=CO2) [C@@H] (C3=C (C=CC=C3) OC) NS (=O) (C4=CC=C (NC (C=C5) =O) C5=C4) =O
Molecular Formula
C28H25N3O6S2
Molecular Weight
563.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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