PBIT
PBIT is a selective cell-permeable inhibitor of JARID1 histone demethylases, including JARID1B (IC50 ~3 μM), JARID1A, and JARID1C. It is a valuable chemical probe for epigenetic research, used in vitro to study the roles of these enzymes in gene regulation, cell differentiation, and cancer biology.
Product Specifications
CAS Number
2514-30-9
Product Name Alternative
PBIT, inhibit, JARID1A, JARID1B, JARID1C, Inhibitor, Histone Demethylase, HistoneDemethylase, Histone Methyltransferase, HistoneMethyltransferase
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
>98%
Bioactivity
JARID1 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
Smiles
CC1=CC=C (C=C1) N1SC2=CC=CC=C2C1=O
Molecular Formula
C14H11NOS
Molecular Weight
241.31
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2- (4-Methylphenyl) -1,2-benzisothiazol-3 (2H) -one
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