PF-05105679
PF-05105679 is a potent and selective TRPM8 antagonist with an IC50 of 103 nM. This compound is a valuable research tool for studying the role of the TRPM8 ion channel in cold sensation and cold-related pain pathologies, applicable in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
1398583-31-7
Product Name Alternative
Clinical, CMR1, cold-related, cold, pain, Inhibitor, inhibit, orally, menthol, melastatin, Transient receptor potential channels, TRPChannel, TRP Channel, TRPM8, TRPV Channel, TRPVChannel, subfamily, PF05105679, PF-05105679, PF 05105679
Field of Research
Pharmacology & Drug Discovery
Purity
99.82% (May vary between batches)
Solubility
DMSO:120 mg/mL (280.08 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.34 mM)
Smiles
C[C@@H] (N (Cc1cccc (c1) C (O) =O) C (=O) c1cnc2ccccc2c1) c1ccc (F) cc1
Molecular Formula
C26H21FN2O3
Molecular Weight
428.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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