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PF-05105679

PF-05105679 is a potent and selective TRPM8 antagonist with an IC50 of 103 nM. This compound is a valuable research tool for studying the role of the TRPM8 ion channel in cold sensation and cold-related pain pathologies, applicable in both in vitro and in vivo experimental models.

Product Specifications

CAS Number

1398583-31-7

Product Name Alternative

Clinical, CMR1, cold-related, cold, pain, Inhibitor, inhibit, orally, menthol, melastatin, Transient receptor potential channels, TRPChannel, TRP Channel, TRPM8, TRPV Channel, TRPVChannel, subfamily, PF05105679, PF-05105679, PF 05105679

Field of Research

Pharmacology & Drug Discovery

Purity

99.82% (May vary between batches)

Solubility

DMSO:120 mg/mL (280.08 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.34 mM)

Smiles

C[C@@H] (N (Cc1cccc (c1) C (O) =O) C (=O) c1cnc2ccccc2c1) c1ccc (F) cc1

Molecular Formula

C26H21FN2O3

Molecular Weight

428.45

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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