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PF-06459988

PF-06459988 is a potent, selective, and irreversible oral inhibitor targeting EGFR mutants, particularly those with T790M resistance mutations, while sparing wild-type EGFR. It serves as a research tool for investigating non-small cell lung cancer (NSCLC) in both cellular and animal models of EGFR-driven tumorigenesis.

Product Specifications

CAS Number

1428774-45-1

Field of Research

Cardiovascular Research, Signal Transduction

Purity

98.00% (May vary between batches)

Smiles

CO[C@H]1CN (C[C@@H]1COc1nc (Nc2cnn (C) c2) nc2[nH]cc (Cl) c12) C (=O) C=C

Molecular Formula

C19H22ClN7O3

Molecular Weight

431.88

Storage Conditions

-20°C

Notes

For research use only.

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