PF-06459988
PF-06459988 is a potent, selective, and irreversible oral inhibitor targeting EGFR mutants, particularly those with T790M resistance mutations, while sparing wild-type EGFR. It serves as a research tool for investigating non-small cell lung cancer (NSCLC) in both cellular and animal models of EGFR-driven tumorigenesis.
Product Specifications
CAS Number
1428774-45-1
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.00% (May vary between batches)
Smiles
CO[C@H]1CN (C[C@@H]1COc1nc (Nc2cnn (C) c2) nc2[nH]cc (Cl) c12) C (=O) C=C
Molecular Formula
C19H22ClN7O3
Molecular Weight
431.88
Storage Conditions
-20°C
Notes
For research use only.
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