Ned 19

Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM[1]. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice[2].

Product Specifications

CAS Number

[874374-25-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ned-19.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC(C(C1)NC(C2=CC=C(OC)C(CN3CCN(C4=CC=CC=C4F)CC3)=C2)C5=C1C6=C(N5)C=CC=C6)=O

Molecular Formula

C30H31FN4O3

Molecular Weight

514.59

Precautions

H302, H315, H319, H335

References & Citations

[1]Rosen D, et al. Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonistNed-19 indicate two binding sites on the NAADP receptor. J Biol Chem. 2009 Dec 11;284 (50) :34930-4.|[2]Annarita Favia, et al. NAADP-Dependent Ca2+ Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis. Sci Rep. 2016; 6: 18925.