Philanthotoxin 74 dihydrochloride
Philanthotoxin 74 dihydrochloride is a selective AMPA receptor antagonist, exhibiting potent inhibitory activity against GluR1 and GluR3 subunits with IC50 values in the nanomolar range. This tool compound is widely used in neuroscience research to investigate glutamatergic signaling, synaptic plasticity, and excitotoxicity in both cellular and animal models.
Product Specifications
CAS Number
1227301-51-0
Product Name Alternative
GluR3, GluR1, GluR5, AMPAR, PhTx 74, PhTx 74 dihydrochloride, PhTx 74 Dihydrochloride, PhTx-74 HCl, Philanthotoxin 74, Philanthotoxin 74 Dihydrochloride
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.60% (May vary between batches)
Solubility
H2O:40 mg/mL (78.81 mM) ; DMSO:90 mg/mL (177.33 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.5 mM)
Smiles
OC (C=C1) =CC=C1C[C@H] (NC (CCC) =O) C (NCCCCCCCNCCCCN) =O.Cl.Cl
Molecular Formula
C24H44Cl2N4O3
Molecular Weight
507.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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