C16
PKR-IN-C16 is a selective ATP-competitive inhibitor of the protein kinase PKR, blocking its autophosphorylation with an IC50 of ~200 nM. It alleviates PKR-mediated translational blockade and protects neuronal cells from ER stress-induced damage, making it a valuable tool for studying neuroprotection and stress response pathways in vitro.
Product Specifications
CAS Number
608512-97-6
Product Name Alternative
PKR, PKRINC16, PKR-IN-C16, PKR-IN-C-16, PKR IN C16, SH-SY5Y, Inhibitor, inhibit, acute brain lesions, Apoptosis
Field of Research
Cell Biology, Neuroscience
Purity
>98%
Bioactivity
PKR kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 15 mg/ml, with warming) .
Smiles
O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1
Molecular Formula
C13H8N4OS
Molecular Weight
268.30
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
6,8-Dihydro-8- (1H-imidazol-5-ylmethylene) -7H-pyrrolo[2,3-g]benzothiazol-7-one
Available Sizes
Frequently Asked Questions
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