Praliciguat
Praliciguat (IW-1973) is an orally bioavailable stimulator of soluble guanylate cyclase (sGC), demonstrating an EC50 of 197 nM in HEK-293 cells. It functions by enhancing nitric oxide signaling, leading to vasodilation, and is utilized in cardiovascular and metabolic disease research in both in vitro and in vivo models.
Product Specifications
CAS Number
1628730-49-3
Product Name Alternative
SGC, Praliciguat, IW 1973, IW1973, IW-1973, inhibit, Inhibitor, Guanylate cyclase, Guanylate Cyclase, Guanylatecyclase
Field of Research
Pharmacology & Drug Discovery
Purity
98.82% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.36 mM) ; DMSO:245 mg/mL (458.49 mM)
Smiles
OC (CNc1nc (ncc1F) -c1cc (-c2ccon2) n (Cc2ccccc2F) n1) (C (F) (F) F) C (F) (F) F
Molecular Formula
C21H14F8N6O2
Molecular Weight
534.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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