Crizotinib
Crizotinib (PF-02341066) is an ATP-competitive small molecule inhibitor of ALK, c-MET, and ROS1 tyrosine kinases. It demonstrates potent antitumor activity in vitro and has shown efficacy in inhibiting tumor growth in preclinical in vivo models of ALK-rearranged cancers.
Product Specifications
CAS Number
877399-52-5
Product Name Alternative
PF-02341066; PF-1066
Field of Research
Cardiovascular Research, Cell Biology
Purity
>98%
Bioactivity
C-MET and ALK inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming)
Smiles
O ([C@H] (C) C1=C (Cl) C (F) =CC=C1Cl) C2=CC (C3=CN (N=C3) C4CCNCC4) =CN=C2N
Molecular Formula
C21H22Cl2FN5O
Molecular Weight
450.34
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3-[ (1R) -1- (2,6-Dichloro-3-fluorophenyl) ethoxy]-5-[1- (4-piperidinyl) -1H-pyrazol-4-yl]-2-pyridinamine
Available Sizes
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