GSK3145095
GSK3145095 is a potent, orally bioavailable RIPK1 inhibitor (IC50 = 5 nM) . It has demonstrated immunomodulatory and anti-cancer activity in preclinical studies, including in vitro assays and in vivo models of pancreatic cancer and systemic inflammation.
Product Specifications
CAS Number
1622849-43-7
Product Name Alternative
Inhibitor, inhibit, GSK3145095, GSK-3145095, GSK 3145095, RIP kinase, RIPK, RIP1 kinase, RIP1, RIPkinase, Receptor-interacting protein kinases
Field of Research
Cell Biology, Signal Transduction
Purity
99.50% (May vary between batches)
Solubility
DMSO:245 mg/mL (616.54 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.58 mM)
Smiles
Fc1cc (F) c2NC (=O) [C@H] (CCc2c1) NC (=O) c1n[nH]c (Cc2ccccc2) n1
Molecular Formula
C20H17F2N5O2
Molecular Weight
397.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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