GSK3186899
GSK3186899 is a potent and selective small molecule inhibitor of Cdc2-related kinase 12 (CRK12), demonstrating an EC50 of 1.4 μM against Leishmania donovani. This compound is a valuable chemical probe for studying kinetoplastid biology and has shown efficacy in reducing parasite load in murine models of visceral leishmaniasis.
Product Specifications
CAS Number
1972617-87-0
Product Name Alternative
CRK12, DDD853651, DDD-853651, DDD 853651, 3,3,3-trifluoro-N-[4-[[3-[ (2R) -2-methylmorpholin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]propane-1-sulfonamide, L. donovani, GSK 3186899, GSK3186899, GSK-3186899
Field of Research
Infectious Disease & Virology
Purity
98.00% (May vary between batches)
Solubility
DMSO:200 mg/mL (406.89 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.17 mM)
Smiles
C[C@H]1CN (CCO1) c1n[nH]c2nc (N[C@H]3CC[C@@H] (CC3) NS (=O) (=O) CCC (F) (F) F) ncc12
Molecular Formula
C19H28F3N7O3S
Molecular Weight
491.53
Storage Conditions
-20°C
Notes
For research use only.
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