Hycanthone
Hycanthone mesylate is a potent antischistosomal agent that functions as a DNA intercalator, inhibiting RNA synthesis and topoisomerases I/II. It also directly binds and inhibits APE1 (KD: 10 nM), disrupting nucleic acid biosynthesis. This compound has been utilized in molecular parasitology research, including studies on schistosome infection models.
Product Specifications
CAS Number
3105-97-3
Product Name Alternative
Parasite, nucleic, Lucanthone, inhibit, Hycanthone, Etrenol (mesylate), endonuclease-1, Inhibitor, intercalator, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, acid, anti-schistosomal, apurinic, APE1, biosynthesis, RNA Synthesis, RNASynthesis, Win 249-33, thioxanthenone, Topoisomerase II, Topoisomerase I, Topoisomerase
Field of Research
Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.78% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.81 mM) ; H2O:< 0.1 mg/mL (insoluble) ; DMSO:18 mg/mL (50.49 mM)
Smiles
CCN (CC) CCNc1ccc (CO) c2sc3ccccc3c (=O) c12
Molecular Formula
C20H24N2O2S
Molecular Weight
356.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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