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ICA-27243

ICA-27243 is a potent, orally bioavailable opener of KCNQ2/Q3 potassium channels (EC50: 0.38 μM) with demonstrated antiepileptic activity in animal models. It shows reduced efficacy on KCNQ4 and KCNQ3/Q5 channels, making it a selective tool for researching neuronal excitability and neuropathic pain in vitro and in vivo.

Product Specifications

CAS Number

325457-89-4

Product Name Alternative

Potassium Channel, PotassiumChannel, KCNQ3, KCNQ2/Q3 potassium channel, KCNQ2, inhibit, Inhibitor, KcsA, opener, hyperpolarization, ICA-27243, ICA27243, ICA 27243, antiepileptic, anticonvulsant

Field of Research

Pharmacology & Drug Discovery

Purity

99.54% (May vary between batches)

Solubility

DMSO:247 mg/mL (919.41 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (12.28 mM)

Smiles

Fc1ccc (cc1F) C (=O) Nc1ccc (Cl) nc1

Molecular Formula

C12H7ClF2N2O

Molecular Weight

268.65

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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