IDH889
IDH889 is a brain-penetrant, allosteric inhibitor that selectively targets mutant IDH1 R132H/C over the wild-type enzyme. This selectivity makes it a valuable research tool for investigating mutant IDH1-driven pathologies, such as glioma, in both cellular and animal models.
Product Specifications
CAS Number
1429179-07-6
Product Name Alternative
Inhibitor, inhibit, Isocitrate Dehydrogenase (IDH), IDH1wt, IDH889, IDH-889, IDH1-R132H, IDH1R132H, IDH 889, IDH1R132C, IDH1-R132C
Field of Research
Metabolism Research
Purity
≥98% (May vary between batches)
Solubility
DMSO:60 mg/mL (137.46 mM) ;10% DMSO+90% Corn Oil:5 mg/mL (11.46 mM)
Smiles
CC (C) [C@H]1COC (=O) N1c1ccnc (N[C@@H] (C) c2ncc (cn2) -c2ccc (F) c (C) c2) n1
Molecular Formula
C23H25FN6O2
Molecular Weight
436.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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