IU1-47
IU1-47 is a potent and selective inhibitor of the deubiquitinase USP14 (IC50 = 0.6 μM) with weaker activity against IsoT/USP5 (IC50 = 20 μM) . It promotes tau clearance in neuronal cultures and is a valuable research tool for studying proteasome function, protein aggregation, and neurodegenerative disease models in vitro.
Product Specifications
CAS Number
670270-31-2
Product Name Alternative
USP14, Deubiquitinase, DUBs, Inhibitor, IU147, IU-1-47, IU1 47, IU1-47, inhibit, IsoT/USP5
Field of Research
Cell Biology, Molecular Biology, Protein Biochemistry
Purity
98.94% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.02 mM) ; DMSO:9 mg/mL (27.2 mM)
Smiles
Cc1cc (C (=O) CN2CCCCC2) c (C) n1-c1ccc (Cl) cc1
Molecular Formula
C19H23ClN2O
Molecular Weight
330.85
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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