JH-RE-06
JH-RE-06 is a small molecule inhibitor of the REV1-REV7 interaction, effectively blocking mutagenic POLζ recruitment during translesion synthesis (IC50=0.78 μM) . It serves as a chemical probe for studying DNA damage tolerance and has shown potential to enhance chemotherapy efficacy in preclinical cancer models.
Product Specifications
CAS Number
1361227-90-8
Product Name Alternative
RNA Synthesis, RNASynthesis, REV1-REV7, Inhibitor, inhibit, JH RE 06, JH-RE-06, JHRE06, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis
Field of Research
Cell Biology, Molecular Biology
Purity
99.24% (May vary between batches)
Solubility
DMSO:10.91 mg/mL (23.28 mM)
Smiles
CC (C) CC (=O) c1c (Nc2ccc (Cl) cc2Cl) [nH]c2c (Cl) ccc ([N+] ([O-]) =O) c2c1=O
Molecular Formula
C20H16Cl3N3O4
Molecular Weight
468.72
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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