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JNJ-10198409

JNJ-10198409 is a potent, ATP-competitive, and relatively selective inhibitor of platelet-derived growth factor receptor tyrosine kinases (PDGFRs), with IC50 values of 4.2 nM for PDGFR-β and 45 nM for PDGFR-α. This dual-mechanism agent exhibits antiangiogenic and direct antiproliferative activity, making it a useful research tool for studying PDGF signaling in cancer and fibrosis models both in vitro and in vivo.

Product Specifications

CAS Number

627518-40-5

Product Name Alternative

Platelet-derived growth factor receptor, PDGFRα, PDGFRβ, Inhibitor, JNJ 10198409, JNJ-​10198409, JNJ10198409, JNJ-10198409, inhibit, PDGFR

Field of Research

Cardiovascular Research, Signal Transduction

Purity

95.55% (May vary between batches)

Solubility

DMSO:83.33 mg/mL (256.13 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.14 mM)

Smiles

COc1cc2Cc3c (Nc4cccc (F) c4) n[nH]c3-c2cc1OC

Molecular Formula

C18H16FN3O2

Molecular Weight

325.34

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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