JNJ-61432059
JNJ-61432059 is a potent, orally bioavailable, and selective negative allosteric modulator of TARP γ‐8-associated AMPA receptors (pIC50 = 9.7) . This compound is a valuable research tool for investigating AMPA receptor function in neurological disorders and has demonstrated utility in both in vitro assays and in vivo preclinical models.
Product Specifications
CAS Number
2035814-50-5
Product Name Alternative
AMPAR, inhibit, Ionotropic glutamate receptors, JNJ 61432059, JNJ61432059, JNJ-61432059, iGluR, Inhibitor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.13% (May vary between batches)
Solubility
DMSO:65 mg/mL (146.57 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.51 mM)
Smiles
OC1CCN (CC1) c1nccc2c (c (nn12) -c1ccc (F) cc1) -c1ccc2NC (=O) Cc2c1
Molecular Formula
C25H22FN5O2
Molecular Weight
443.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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