Ketohexokinase inhibitor 1
This compound is a potent and selective inhibitor of ketohexokinase (KHK), exhibiting greater potency against the KHK-C isoform (IC50 = 8.4 nM) than the KHK-A isoform (IC50 = 66 nM) . It is a valuable research tool for investigating fructose metabolism in models of metabolic diseases, including non-alcoholic fatty liver disease (NAFLD) and diabetes, in both cellular and animal studies.
Product Specifications
CAS Number
2102501-84-6
Product Name Alternative
KHK-A, KHK-C, Ketohexokinase inhibitor 1, PF 06835919, PF06835919, PF-06835919
Field of Research
Pharmacology & Drug Discovery
Purity
97.02% (May vary between batches)
Solubility
DMSO:125 mg/mL (350.79 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.23 mM)
Smiles
C (C (O) =O) [C@@H]1[C@@]2 ([C@]1 (CN (C2) C3=NC (=NC (C (F) (F) F) =C3) N4[C@@H] (C) CC4) [H]) [H]
Molecular Formula
C16H19F3N4O2
Molecular Weight
356.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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