L-161982
L-161982 is a selective EP4 prostaglandin receptor antagonist. It suppresses PGE2-mediated ERK phosphorylation and proliferation in HCA-7 colon carcinoma cells in vitro and demonstrates efficacy in a murine collagen-induced arthritis model, supporting research in oncology and inflammation.
Product Specifications
CAS Number
147776-06-5
Product Name Alternative
Colon, arthritis, cancer, inhibit, L 161982, EP4, Inhibitor, L161982, L-161982, phosphorylation, proliferation, prostaglandin, ProstaglandinReceptor, Prostaglandin Receptor
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
99.44% (May vary between batches)
Solubility
DMSO:9 mg/mL (13.75 mM) ;10% DMSO+90% Corn Oil:0.5 mg/mL (0.76 mM)
Smiles
O=C1N (N=C (CCCC) N1CC2=CC=C (C=C2) C3=C (S (NC (=O) C4=C (C) C=CS4) (=O) =O) C=CC=C3) C5=C (C (F) (F) F) C=CC=C5
Molecular Formula
C32H29F3N4O4S2
Molecular Weight
654.72
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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