Laropiprant
Laropiprant (MK-0524) is a potent, selective antagonist of the prostaglandin D2 receptor DP1 (Ki = 0.57 nM) with additional activity at the TP receptor (Ki = 2.95 nM) . This small molecule is a valuable research tool for investigating the roles of PGD2 signaling in allergic responses, inflammation, and cardiovascular research in both in vitro and in vivo models.
Product Specifications
CAS Number
571170-77-9
Product Name Alternative
Metabolismacyl, MK 0524, MK0524, MK-0524, inhibit, Inhibitor, Laropiprant, glucuronide, DP/DP1 Receptor, DP receptor, pharmacokinetics, TP Receptor, ProstaglandinReceptor, Prostaglandin Receptor
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
98.24% (May vary between batches)
Solubility
DMSO:100 mg/mL (229.41 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.18 mM)
Smiles
CS (=O) (=O) c1cc (F) cc2c3CC[C@H] (CC (O) =O) c3n (Cc3ccc (Cl) cc3) c12
Molecular Formula
C21H19ClFNO4S
Molecular Weight
435.9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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