Sonidegib diphosphate
Sonidegib diphosphate is a potent and selective Smoothened (Smo) antagonist, with IC50 values of 1.3 nM and 2.5 nM for murine and human targets, respectively. This tool compound is widely used in vitro and in vivo for researching Hedgehog pathway-driven cancers, such as basal cell carcinoma and medulloblastoma.
Product Specifications
CAS Number
1218778-77-8
Product Name Alternative
LDE 225, LDE 225 Diphosphate, LDE225, LDE-225, LDE225 diphosphate, LDE-225 Diphosphate, Erismodegib, Erismodegib diphosphate, hSmo, NVP-LDE 225, NVP-LDE 225 diphosphate, NVP-LDE225, NVP-LDE-225, NVP-LDE-225 Diphosphate, mSmo, Smo, Sonidegib
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
99.48% (May vary between batches)
Solubility
DMSO:99 mg/mL (145.27 mM) ; H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.84 mM)
Smiles
OP (O) (O) =O.OP (O) (O) =O.C[C@H]1CN (C[C@@H] (C) O1) c1ccc (NC (=O) c2cccc (-c3ccc (OC (F) (F) F) cc3) c2C) cn1
Molecular Formula
C26H32F3N3O11P2
Molecular Weight
681.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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