Leptomycin B
Leptomycin B is a potent antifungal antibiotic and cell cycle blocker that covalently inactivates CRM1/exportin 1, inhibiting nuclear protein export. It is widely used in vitro and in vivo to study nucleocytoplasmic transport, cell cycle regulation, and cancer research.
Product Specifications
CAS Number
87081-35-4
Product Name Alternative
Chromosomal Maintenance 1, CI 940, CI940, CI-940, CRM1/exportin 1, CRM1, Antibiotic, cancer, mutation, inhibit, KRAS, LMB, p53, NSCLC, nuclear export, EGFR, Exportin 1, EMT, Fungal, Inhibitor, Leptomycin B, XPO1, resistance
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
>98%
Bioactivity
Nuclear export inhibitor
Form
Soln in ethanol
Solubility
Supplied in solution in ethanol (1 mg/ml) . Further dilutions may be made with either ethanol or DMSO.
Smiles
C (=C/C (=C\[C@@H] (C/C=C/C (=C/[C@H] (C ([C@H] ([C@@H] ([C@H] (C/C (=C/C (O) =O) /C) C) O) C) =O) C) /C) C) /CC) \[C@H]1[C@@H] (C) C=CC (=O) O1
Molecular Formula
C33H48O6
Molecular Weight
540.75
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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