LUT014
LUT014 is a potent B-Raf inhibitor (IC50: 11.7 nM) developed to mitigate EGFR inhibitor-induced acneiform lesions. It is a research tool for studying targeted therapy combinations and resistance mechanisms in oncology, applicable in both in vitro and in vivo models of skin toxicity and cancer.
Product Specifications
CAS Number
2274819-46-2
Product Name Alternative
Inhibitor, LUT 014, LUT014, LUT-014, inhibit, B-Raf, Raf kinases, Raf
Field of Research
Signal Transduction
Purity
96.34% (May vary between batches)
Solubility
DMSO:50 mg/mL (94.61 mM) ; H2O:< 0.1 mg/mL (insoluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.78 mM)
Smiles
Cc1ccc2c (Nc3cccc (OC (F) (F) F) c3) nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12
Molecular Formula
C27H19F3N8O
Molecular Weight
528.49
Storage Conditions
-20°C
Notes
For research use only.
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