LY 345899
LY 345899 is a folate analog that potently inhibits methylenetetrahydrofolate dehydrogenase enzymes, with an IC50 of 96 nM for MTHFD2 and a Ki of 18 nM for MTHFD1. This inhibitor is a valuable research tool for studying one-carbon metabolism in cancer cell proliferation and has been utilized in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
10538-99-5
Product Name Alternative
LY 345899, LY345899, LY-345899, Methylenetetrahydrofolate Dehydrogenase (MTHFD), inhibit, MTHFD1, Inhibitor
Field of Research
Cell Biology, Metabolism Research, Molecular Biology
Purity
99.69% (May vary between batches)
Solubility
DMSO:60 mg/mL (127.28 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.24 mM)
Smiles
Nc1nc2NCC3CN (C (=O) N3c2c (=O) [nH]1) c1ccc (cc1) C (=O) N[C@@H] (CCC (O) =O) C (O) =O
Molecular Formula
C20H21N7O7
Molecular Weight
471.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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