Mal-amido-PEG8-NHS ester
Mal-amido-PEG8-NHS ester is a heterobifunctional PROTAC linker featuring a maleimide group for cysteine conjugation and an NHS ester for amine coupling. This water-soluble PEG-based spacer is widely used in constructing proteolysis-targeting chimeras (PROTACs) for both in vitro and in vivo targeted protein degradation studies.
Product Specifications
CAS Number
756525-93-6
Product Name Alternative
Alkyl/ether, PEGs, inhibit, Inhibitor, MalamidoPEG8NHS ester, Mal-amido-PEG-8-NHS ester, Mal-amido-PEG8-NHS ester, Mal amido PEG8 NHS ester, PROTACLinker, PROTAC Linker, PROTAC Linkers
Field of Research
Pharmacology & Drug Discovery
Purity
≥98% (May vary between batches)
Solubility
DMSO:10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.9 mM)
Smiles
O (C (CCOCCOCCOCCOCCOCCOCCOCCOCCNC (CCN1C (=O) C=CC1=O) =O) =O) N2C (=O) CCC2=O
Molecular Formula
C30H47N3O15
Molecular Weight
689.71
Storage Conditions
-20°C
Notes
For research use only.
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