PS210
PS210 is a potent and selective PDK1 activator (Kd: 3 μM) that binds its PIF pocket without affecting kinases like S6K or Akt. Its prodrug, PS423, acts as a substrate-selective cellular PDK1 inhibitor, blocking S6K phosphorylation. These compounds are valuable research tools for studying PDK1-dependent signaling pathways in cancer and metabolic disease models.
Product Specifications
CAS Number
1221962-86-2
Product Name Alternative
A-B, Arg131, inhibit, Lys76, Inhibitor, helix, Thr148, pocket, PDK-1, PDK1, PIF-binding, PIFtide, PS 210, PS210, PS-210, PS423, S6K
Field of Research
Signal Transduction
Purity
99.65% (May vary between batches)
Solubility
DMSO:60 mg/mL (157.77 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)
Smiles
OC (=O) C (C (CC (=O) c1ccc (cc1) C (F) (F) F) c1ccccc1) C (O) =O
Molecular Formula
C19H15F3O5
Molecular Weight
380.31
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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