Roniciclib
Roniciclib (BAY 1000394) is a novel, orally bioavailable pan-cyclin-dependent kinase (CDK) inhibitor. It potently suppresses cell-cycle (CDK1/2/3/4) and transcriptional (CDK7/9) kinases with IC50 values of 5-25 nM. This small molecule is utilized in cancer research to study cell cycle arrest and apoptosis in both in vitro and in vivo models.
Product Specifications
CAS Number
1223498-69-8
Product Name Alternative
Cyclin dependent kinase, CDK7/Cyclin H/MAT1, CDK9/cyclin T1, CDK9/cyclinT1, CDK3/cyclinE, CDK4/cyclin D, CDK4/CyclinD, CDK2/cyclinE, CDK, CDK1/CyclinB, Cdk1/cyclin B, BAY 1000394, BAY1000394, BAY-1000394, inhibit, Inhibitor, Roniciclib
Field of Research
Cell Biology
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.62 mM) ; DMSO:249 mg/mL (578.48 mM)
Smiles
C[C@@H] (O) [C@@H] (C) Oc1nc (Nc2ccc (cc2) [S@] (=N) (=O) C2CC2) ncc1C (F) (F) F
Molecular Formula
C18H21F3N4O3S
Molecular Weight
430.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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