Desmoglein-3 (Squamous Cell Marker)
Product Specifications
Gene Name
[DSG3]
NCBI Gene ID
1830
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 °C.<br>Antibody without azide - store at -20 to -80 °C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (>80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Other Gene Names
[DSG3; DSG3; PVA; CDHF6; CDHF6; PVA]
Short Name
[Desmoglein-3]
Other Product Names
[desmoglein-3 preproprotein; Desmoglein-3; desmoglein-3; desmoglein 3; 130 kDa pemphigus vulgaris antigen; PVA; Cadherin family member 6]
NCBI GI Number
119964718
NCBI Accession Number
NP_001935.2
NCBI GB Accession Number
NM_001944.2
Uniprot Accession Number
P32926
Available Sizes
Curated Selection
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