Desmoglein-1 (DSG1)
Product Specifications
Gene Name
[DSG1]
NCBI Gene ID
1828
Reactivity
Human. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 °C.<br>Antibody without azide - store at -20 to -80 °C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.
Other Gene Names
[DSG1; DSG1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA; CDHF4; DG1; DGI]
Short Name
[Desmoglein-1 (DSG1)]
Other Product Names
[desmoglein-1 preproprotein; Desmoglein-1; desmoglein-1; desmoglein 1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen]
NCBI GI Number
119703744
NCBI Accession Number
NP_001933.2
NCBI GB Accession Number
NM_001942.3
Uniprot Accession Number
Q02413
Available Sizes
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