Cytochrome p450

Product Specifications

Gene Name

[CYP2E1]

NCBI Gene ID

1571

Reactivity

Human. Others not known.

Storage Conditions

Antibody without azide - store at -20°C to -80°C.<br>Non-hazardous. No MSDS required.

Specificity

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases, which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines, which are pre-mutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Other Gene Names

[CYP2E1; CYP2E1; CPE1; CYP2E; P450-J; P450C2E; CYP2E]

Short Name

[Cytochrome p450]

Other Product Names

[cytochrome P450 2E1; Cytochrome P450 2E1; cytochrome P450 2E1; cytochrome P450 family 2 subfamily E member 1; 4-nitrophenol 2-hydroxylase (EC:1.14.13.n7); CYPIIE1; Cytochrome P450-J]