Catenin, beta (p120)
Product Specifications
Gene Name
[CTNNB1]
NCBI Gene ID
1499
Reactivity
Human, Cow, Dog, Chicken. Others not known.
Storage Conditions
Antibody with azide - store at 2 to 8 °C.<br>Antibody without azide - store at -20 to -80 °C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
This MAb recognizes a protein of 92kDa, which is identified as beta-catenin. It shows no cross-reaction with gamma-catenin (also known as plakoglobin). The catenins, alpha, beta and gamma bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin was initially described as an E-cadherin-associated protein, and has been shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin has also been found in complexes with the tumor suppressor protein APC.
Other Gene Names
[CTNNB1; CTNNB1; EVR7; CTNNB; MRD19; armadillo; CTNNB]
Short Name
[Catenin, beta]
Other Product Names
[catenin beta-1 isoform 1; Catenin beta-1; catenin beta-1; catenin beta 1; Beta-catenin]
NCBI GI Number
148233338
NCBI Accession Number
NP_001091679.1
NCBI GB Accession Number
NM_001098209.1
Uniprot Accession Number
P35222
Available Sizes
Curated Selection
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