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SB-265610

SB-265610 (GSK-CXCR2) is a potent, nonpeptide allosteric antagonist of the CXCR2 receptor. It effectively inhibits CINC-1-induced calcium mobilization and neutrophil chemotaxis with IC50 values of 3.7 nM and 70 nM, respectively. This compound is a valuable research tool for studying CXCR2-mediated inflammatory responses in both cellular and animal models of disease.

Product Specifications

CAS Number

211096-49-0

Product Name Alternative

Inhibitor, nonpeptide, inhibit, inflammation, neutrophil, GSK-CXCR2, healing, Delay, CXCR, CXCR2, CXC chemokine receptors, wound, recruitment, SB265610, SB-265610, SB 265610

Field of Research

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Purity

97.67% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.6 mM) ; DMSO:66 mg/mL (184.79 mM)

Smiles

Brc1ccccc1NC (=O) Nc1ccc (C#N) c2nn[nH]c12

Molecular Formula

C14H9BrN6O

Molecular Weight

357.16

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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