Catenin, alpha-1 (CTNNA1)

Antibody with azide - store at 2 to 8 °C.<br>Antibody without azide - store at -20 to -80 °C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-catenin forms a heterodimer with beta-catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-catenin also regulates the beta-catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.

[catenin alpha-1 isoform 2; Catenin alpha-1; catenin alpha-1; catenin alpha 1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13]