SMCC-DM1
SMCC-DM1 is a chemical linker-payload conjugate designed for constructing antibody-drug conjugates (ADCs) . The cytotoxic agent DM1 inhibits microtubule polymerization, while the SMCC linker enables stable attachment to antibodies. This reagent is widely used in preclinical research for developing targeted cancer therapies, with applications in both in vitro cytotoxicity assays and in vivo xenograft models.
Product Specifications
CAS Number
1228105-51-8
Product Name Alternative
DM1-SMCC, DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC, Drug-Linker Conjugates for ADC, inhibit, Inhibitor, Maytansinoids, SMCC DM1, SMCCDM1, SMCC-DM1, SMCC-DM-1
Field of Research
Pharmacology & Drug Discovery
Purity
97.07% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.86 mM) ; DMSO:90 mg/mL (83.91 mM)
Smiles
CO[C@@H]1\C=C/C=C (C) \Cc2cc (OC) c (Cl) c (c2) N (C) C (=O) C[C@H] (OC (=O) [C@H] (C) N (C) C (=O) CCSC2CC (=O) N (CC3CCC (CC3) C (=O) ON3C (=O) CCC3=O) C2=O) [C@]2 (C) O[C@H]2[C@H] (C) [C@@H]2C[C@@]1 (O) NC (=O) O2
Molecular Formula
C51H66ClN5O16S
Molecular Weight
1072.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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