Smurf1-IN-A01
Smurf1-IN-A01 is a potent small molecule inhibitor of the Smurf1 ubiquitin ligase (Kd = 3.664 nM) . By blocking Smurf1-mediated degradation of Smad1/5, it enhances cellular BMP-2 signaling and is a valuable research tool for studying bone morphogenetic protein pathways in both in vitro and in vivo models.
Product Specifications
CAS Number
1007647-73-5
Product Name Alternative
A01, Smurf1, Smurf1 IN A01, Smurf1INA01, Smurf-1-IN-A01, Smurf1-IN-A01
Field of Research
Immunology & Inflammation, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.46% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.9 mM) ; DMSO:62.5 mg/mL (121.85 mM)
Smiles
Cc1ccnn1-c1ccc (cc1) C (=O) N1CCN (CC1) S (=O) (=O) c1ccc (Cl) c (c1) C (F) (F) F
Molecular Formula
C22H20ClF3N4O3S
Molecular Weight
512.93
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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