Donafenib
Donafenib is a deuterated analog of the multikinase inhibitor Sorafenib. It potently inhibits Raf-1, B-Raf, and VEGFR-3 kinases, making it a valuable research tool for studying oncogenic signaling pathways in both cellular and animal models of cancer.
Product Specifications
CAS Number
1130115-44-4
Product Name Alternative
Sorafenib, Sorafenib (D3), Sorafenib-d3, Raf-1, VEGFR3, Bay 43-9006, Bay 43-9006 (D3), B-Raf
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.88% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.05 mM) ; DMSO:90 mg/mL (192.37 mM)
Smiles
[2H]C ([2H]) ([2H]) NC (=O) c1cc (Oc2ccc (NC (=O) Nc3ccc (Cl) c (c3) C (F) (F) F) cc2) ccn1
Molecular Formula
C21H13ClD3F3N4O3
Molecular Weight
467.84
Storage Conditions
Keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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