TAK-243
TAK-243 (MLN7243) is a potent and selective inhibitor of the ubiquitin-activating enzyme (UAE/UBA1) with an IC50 of 1 nM. It effectively blocks global protein ubiquitination, disrupting key cellular signaling pathways. This mechanism underlies its observed pro-apoptotic and antitumor effects in both in vitro and in vivo cancer research models.
Product Specifications
CAS Number
1450833-55-2
Product Name Alternative
Field of Research
Cell Biology, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction
Purity
98.09% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.62 mM) ; DMSO:237.5 mg/mL (457.15 mM)
Smiles
NS (=O) (=O) OC[C@H]1C[C@@H] (Nc2ccnc3cc (nn23) -c2cccc (SC (F) (F) F) c2) [C@H] (O) [C@@H]1O
Molecular Formula
C19H20F3N5O5S2
Molecular Weight
519.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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