TAK-243
TAK-243 (MLN7243) is a potent and selective inhibitor of the ubiquitin-activating enzyme (UAE/UBA1) with an IC50 of 1 nM. It effectively blocks global protein ubiquitination, disrupting key cellular signaling pathways. This mechanism underlies its observed pro-apoptotic and antitumor effects in both in vitro and in vivo cancer research models.
Product Specifications
CAS Number
1450833-55-2
Product Name Alternative
Field of Research
Cell Biology, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction
Purity
98.09% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.62 mM) ; DMSO:237.5 mg/mL (457.15 mM)
Smiles
NS (=O) (=O) OC[C@H]1C[C@@H] (Nc2ccnc3cc (nn23) -c2cccc (SC (F) (F) F) c2) [C@H] (O) [C@@H]1O
Molecular Formula
C19H20F3N5O5S2
Molecular Weight
519.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Mouse S100 Calcium Binding Protein A8 Chemiluminescent Immunoassay Kit
FAM46B sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
Lentiviral human KLHDC2 sgRNA gene knockout kit - Lentiviral human KLHDC2 sgRNA gene knockout kit (25)