TAS6417
Zipalertinib (TAS6417, CLN-081) is a potent, orally bioavailable covalent EGFR inhibitor targeting the ATP-binding hinge region with low nM IC50 values. It is a research tool for investigating EGFR-driven cancers, demonstrating activity in both cellular assays and in vivo tumor models.
Product Specifications
CAS Number
1661854-97-2
Product Name Alternative
Lung, inhibit, PC-9, NSCLC, H1975, ErbB-1, Epidermal growth factor receptor, EGFR, HER1, Inhibitor, Akt, Apoptosis, BID007, BID019, BEAS-2B, cancer, CLN081, CLN-081, CLN 081, TAS6417, TAS-6417, TAS 6417
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.19% (May vary between batches)
Solubility
DMSO:55 mg/mL (138.73 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (6.31 mM)
Smiles
CC1=C[C@@H] (Cn2c1c (-c1cnc3ccccc3c1) c1c (N) ncnc21) NC (=O) C=C
Molecular Formula
C23H20N6O
Molecular Weight
396.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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