CD22 / BL-CAM Mouse Monoclonal Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

[CD22]

NCBI Gene ID

933

Reactivity

Human.<br>Others not tested

Storage Conditions

Antibody without azide - store at -20 to -80°C. Non-hazardous. No MSDS required.

Specificity

Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.

Other Gene Names

[CD22; CD22; SIGLEC2; SIGLEC-2; SIGLEC2; BL-CAM; Siglec-2]

Short Name

[CD22 / BL-CAM]

Other Product Names

[B-cell receptor CD22 isoform 2; B-cell receptor CD22; B-cell receptor CD22; CD22 molecule; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD_antigen: CD22]