CD46 (Membrane Cofactor Protein) Mouse Monoclonal Antibody
Product Specifications
Gene Name
[CD46]
NCBI Gene ID
4179
Reactivity
Human, Baboon.<br>Does not react with Horse.<br>Others not tested
Storage Conditions
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.
Other Gene Names
[CD46; CD46; MCP; TLX; AHUS2; MIC10; TRA2.10; MCP; MIC10]
Short Name
[CD46]
Other Product Names
[membrane cofactor protein isoform 1; Membrane cofactor protein; membrane cofactor protein; CD46 molecule; TLX; Trophoblast leukocyte common antigen; CD_antigen: CD46]
NCBI GI Number
27502402
NCBI Accession Number
NP_002380.3
NCBI GB Accession Number
NM_002389.4
Uniprot Accession Number
P15529
CAS Number
9007-83-4
Available Sizes
Curated Selection
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