CD55 / Decay Accelerating Factor (DAF) Mouse Monoclonal Antibody
Product Specifications
Gene Name
[CD55]
NCBI Gene ID
1604
Reactivity
Human
Storage Conditions
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a single chain glycoprotein of 70kDa, identified as CD55 (also known as decay accelerating factor, DAF). CD55/DAF is widely expressed on cells throughout the body including leukocytes, erythrocytes, epithelium, endothelium, and fibroblasts. It is a Glycosyl phosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. It prevents the amplification steps of the complement cascade by interfering with the assembly of the C3-convertases, C4b2a and C3bBb, and the C5-convertase, C4b2a3b and C3bBb3b. CD55 also serves as receptor for CD97 and for echovirus and Coxsackie B virus. The MAb 143-30 can be used as marker for paroxysmal nocturnal hemoglobinuria (PNH).
Other Gene Names
[CD55; CD55; CR; TC; DAF; CROM; CR; DAF]
Short Name
[CD55 / Decay Accelerating Factor (DAF)]
Other Product Names
[complement decay-accelerating factor isoform 1 preproprotein; Complement decay-accelerating factor; complement decay-accelerating factor; CD55 molecule (Cromer blood group); CD_antigen: CD55]
NCBI GI Number
10835143
NCBI Accession Number
NP_000565.1
NCBI GB Accession Number
NM_000574.4
Uniprot Accession Number
P08174
CAS Number
9007-83-4
Available Sizes
Curated Selection
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