Toyocamycin
Toyocamycin (Vengicide) is an adenosine analog and potent XBP1 inhibitor, blocking IRE1α-mediated XBP1 mRNA splicing with an IC50 of 80 nM. This activity induces apoptosis, making it a valuable tool for studying the unfolded protein response in cancer and other disease models, both in vitro and in vivo.
Product Specifications
CAS Number
606-58-6
Product Name Alternative
7-Deaza-7-cyanoadenosine; NSC 63701; NSC 99843; Neuro 000027; Unamycin B; Vengicide
Field of Research
Cell Biology, Neuroscience, Protein Biochemistry
Purity
>98%
Bioactivity
RNA self cleavage inhibitor; antitumor activity
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml)
Smiles
Nc1ncnc2n (cc (C#N) c12) [C@@H]1O[C@H] (CO) [C@@H] (O) [C@H]1O
Molecular Formula
C12H13N5O4
Molecular Weight
291.26
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Available Sizes
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